Joe Manganiello reveals secret health battle, 'live-saving' organ removal

Taijuan Moorman, USA TODAYWed, June 24, 2026 at 1:23 PM UTC

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Joe Manganiello will soon open up about a multi-yearlong health battle that changed his life completely.

The "True Blood" and "One Piece" actor is set to release a memoir this fall, detailing the seven-year period during which he experienced a "cascade of autoimmune-related illnesses" amid a "new marriage" and at the peak of his career.

Per the book's description, "Bloodlines" is a "gripping memoir of a previously undisclosed health ordeal – marked by multiple near-death experiences and medical crises – that led him beyond medicine and into a remarkable, globe-spanning quest that revealed answers about his ancestry, inherited trauma, and the deeper histories we carry."

Per the synopsis of the memoir, arriving Oct. 13 from Simon & Schuster imprint Avid Reader Press, the conditions "attacked his skin, thyroid, eyes, lungs, and digestive system" and required the actor to undergo "a life-saving organ amputation."

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Joe Manganiello attends Netflix's "Nonnas" world premiere at The Plaza Hotel on April 30, 2025, in New York City.

Manganiello, 49, also fell into an "existential crisis" as doctors had "few answers and no clear explanation" of what was happening to him.

"An unorthodox path emerged – shamans, pagan rituals, ancient myths, long lost family records, and the rebirth of his own spirituality," the description continued. "A search that led him deep into his own bloodline: to a survivor of the Armenian genocide, to ancestors shaped by violence and displacement, and the hidden patterns shared by others living with chronic illness."

The "Nonnas" actor called the trial "the most brutally difficult time of my life" as well as "my greatest adventure," in a statement shared exclusively with People. "The process of writing this book gave me the gift of perspective that helped me to see that my suffering was a cocoon from which I would emerge forever changed."

The health ordeal seems to have been in the mid-2010s, as Manganiello married actress Sofía Vergara in 2015. The pair divorced in 2023, with Vergara later attributing the split to differing views on having children, which Manganiello disputed.

This article originally appeared on USA TODAY: Joe Manganiello memoir 'Bloodlines' to detail secret health battle

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